Description of
MEBO and Clincal Pharmacology
DESCRIPTION:
Light
yellow-brown ointment with sesame oil smell
CLINICAL PHARMACOLOGY:
1. Skin
Regeneration
The first
therapeutic effect of MEBO on cutaneous wound healing is skin
regeneration.
MEBO can achieve wound healing without scar formation
after deep burns, which will be able to regenerate the new skin on the
deep burn wounds and other wounds caused by other etiology like bed
sores, diabetes wounds,
skin ulcers,
etc., in which the wounds indeed
healed without scar formation.
The cells expressing skin
stem cell
cytokeratin-19, which is undetectable in normal tissues by
the
technique, were observed in the wounds 24-hours after the application
of MEBO treatment.
The number of these cells reached a peak level
within 7-14 days, and gradually reduced as the wound healing process
concluded.
2. Analgesic
Effects
MEBO relieve
wound pains by non-anesthesia ways.
It can increase pain
threshold and effectively reduce stimulation of pain.
External stimuli
could be resisted by protective layer of MEBO formed on injured nerve
ending, which may enhance the pain threshold to reduce the pain.
Within
10 seconds of application of MEBO, pain on the wound is
eliminated.
For
some patients it took 2-3 minutes to eliminate the pain.
MEBO exerts the
analgesic effects throughout the whole wound healing process.
3. Prevention
and Control of Infection
MEBO has
achieved very
good anti-infection effects on numerous
patients, some of them even with extensive deep burns for the past
decade.
The curate and survival rate of massive
burns has been raised
from 50% to 91%.
Through clinical studies and relevant research, MEBO
was found
to be able to reduce the pathogenic toxicity of bacterial toxin, which
validated that MEBO causes transformation of bacteria and reduces
production of toxin.
During the treatment, the number of pathogenic
bacteria for living tissues on burn wound surface is in the limit of
non-infection.
4.
Anti-inflammatory Effects
Mebo can
reduce swelling and inflammatory reaction on the wound and
promote burn patient’s immunity and wound healing.
The test
of
Xylene-induced ear edema and the edema of hind paw induced by injection
of agar in rats demonstrated that MEBO had reliable
inflammatory
effects.
INDICATION/
USES:
APPLICATION
AND DOSAGE:
For external
use.
Apply onto wounds caused by burns, scalds, chemical
burns etc. at a thickness of not more than 1 mm and renew the
ointment
every 4 to 6 hours.
Before the renewal, the
residual ointment and
liquefied products should be wiped off.
Expose the wound when
application.
CONTRAINDICATION:
MEBO should be
used with special care for patient hypersensitive to
sesame oil.
PRECAUTION:
- Patients developing systemic signs derived from
burns
wounds should be treated under the supevision of doctors specializing
in “Burn therapy with skin organ regeneration in situ with
MEBT/MEBO.
- Repeated squeezing and crashing may soften and
thin
the ointment, especially in summer, which will not affect its
therapeutic efficacy. When it occurs, soak the screwed-tube in boiling
water for several minutes and then stand to cool, its dosage form will
return to normal.
- For ordinary wounds such as bedsores, diabetes
wound,
skin ulcers, etc., please refer to the MEBO’s
users’
guidelines and/or follow medical advice respectively.
SPECIFICATION:
40g per tube
STORAGE: Store
the ointment in a cool place.
PACKAGE: Aluminum-plastic
compound tube
SHELF LIFE:
36 months
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