Skin soft tissue impairments can result from both congenital and acquired causes. 

1. Congenital causes are concerned with intrauterine infection of the fetus; 
2. acquired cause is related to traumas and local infection. 

In the past, operation therapy was taken to treat these diseases, but its expense was high, and it was difficult to be accepted by patients and their relatives. 

Zhao Xiong etc. [15] treated 8 cases of new-born congenital skin defect with 1%-15% defect area. Defect parts: 5 lower extremity defect cases, 2 upper extremity defect cases, and 1 trunk defect case. The average healing time was 7-21 days. There was no infection, necrosis or scar, and the skin had good elasticity. The author thought MEBO was an ideal drug for treating congenital skin defects. 

Zhang HZ etc. [16] treated 19 cases of finger tip defects due to traumas with MEBO. All the patients were healed without apparent infection. The shortness of affected fingers was not obvious after they were healed, there was no obvious dysfunction, and the unbroken nails in the nail bed were reproducible. 

Qu YB etc. [17] compared MEBO therapy with routine surgical dressing change method in treating infected small-area scalp defects after traumas with the results as follows: the healing time was shorter with MEBO therapy, and local pains and hemorrhage etc. were avoided. 

Su YT etc. [18] cured 5 cases of small-area exposed bone with MEBO bandage, and 6 cases of large-area exposed bone with MEBO bandage, bone cortex drilling and skin grafting. 

Wei JG etc. [19] treated 40 cases of large-area avulsion injury wound with skin flap necrosis after debridement and stitching in original position with MEBO treatment in the whole treatment process. All the wounds were healed physiologically. The skin had good elasticity and normal color without cicatricial contracture sotomy, ankylosis, infection, or sepsis. Among the 40 cases, 30 cases had open fracture, and the wound with maximal area is 32 cm × 13 cm.

Refernce:
15. Zhao X. Clinical Analysis of Using MEBO to Treat 8 Cases Of New-born Congenital Skin Defect [J]. The Chinese Journal of Burns Wounds & Surface Ulcers. 1998, (2): p. 52-53.
16. Zhang Z., Cao X., Bi Y. Experiences of 19 Cases Using MEBO to Treat Amputed Finger End [J]. The Chinese Journal of Burns Wounds & Surface Ulcers. 1999, (3): p. 34-35.
17. Qu Y., Li C., Zhang G. Analysis on the Curative Effects of MEBO in Treating Infected Small-area Scalp Defect After Traumas [J]. The Chinese Journal of Burns Wounds & Surface Ulcers. 2002, 14 (1): p. 39-40.
18. Su Y., Xing X., Zhao J. etc. Treating Exposed Bone with MEBO Pressing Bandaging Strapping [J]. The Chinese Journal of Burns Wounds & Surface Ulcers. 2002, 14 (3): p. 172-174.
19. Wei J., Wang B., Cheng J. etc. Treating Large-area Skin Avulsion And Necrosis With MEBO [J]. The Chinese Journal of Burns Wounds & Surface Ulcers. 2001, 13 (3): p. 190-191.