To find a method for treating skin and soft tissue abrasion caused by accidents.

In MEBO group, the average healing time of the wounds was 7.32 days, significantly shorter than that in the complex iodine group.

Method
1. Local treatment: In MEBO group, MEBO was spread onto the wound directly 2 times a day with a thickness of 1 mm after the wound was debrided thoroughly. Exposed therapy or bandaging method was adopted according to the condition of the wound. In the control group, complex iodine was applied 2 times a day to the lesion area with exposed or bandaged method according to the condition of the lesion area after it was debrided thoroughly.

2. Systematic treatment: Antibacterial wasn’t supplied for prevention to the patients that were not serious. Amoxicillin was supplied for prevention for 3~7 days to the patients with serious pollution or sensitive antibiotics were used until the infection of the wound was controlled.

Discussion
1. Scars would form after the breakage and abrasion of full-thickness skin. In addition, the traditional dry bandaging therapy would lead the tissues to necrosis and would affect the regeneration of endepidermis when treating open burns. The effect was not as good as moist therapeutics [1]. 

MEBT (Moist Exposed Burn Therapeutics) could activate the endepidermis regenerative stem cells to proliferate [2]. MEBO has good effect in treating large area burn and scalded patients [3]. It also has fine curative effect in treating skin and mucosa defect [4~8]. 

The wound healed without scar formation and without functional obstacle after treatment [1~8]. The application of MEBO in treating skin and soft tissue abrasion could shorten the healing time and decrease the formation rate of scars significantly after healing (in MEBO group, it was 5.92%; in the control group, it was 20.67%.). 

The average healing time in MEBO group was 7.32 days while in the control group, the average healing time was 11.25 days.

2. The biform distribution and draining function of MEBO at the wound isolated air from the wound effectively.

The irradiation and damage to the wound because of exposition, dryness and air contact were avoided. It could promote the recovery of the local microcirculation and could decrease the stimulation and pressure to the nerve terminal caused by oxygen deficiency and turgescence of the tissues.

So MEBO has analgesic and antipruritic functions. The patients didn’t feel pain or only slight pain when the wound dressing was changed using MEBO to treat skin and soft tissue abrasion in the clinical observation. The odynolysis effect was fast and significant. The pain that the patients suffered was not strong and the bearing ability of patients was good. 

It was more suitable for children, aged persons or persons with relatively poor bearing ability to use. 

In the control group, all the patients suffered obvious ache and they even needed painkiller.

3. MEBO could lead to the configuration variation of E.coli, Bacillus, Staphylococcus aureus and Pseudomonas aeruginosa. The pigment of Pseudomonas aeruginosa disappeared and the ability of producing plasma-coagulase of Staphylococcus aureus decreased. The metabolism and composition speed of germs slowed down. The growth and reproduction speed and the toxin were affected. It had broad-spectrum antibacterial effects on Bacillus tetani, Bacteroides fragilitas, Propionibacterium acne and fungus. 

The incidence rate of infection at the lesion area in MEBO group was lower than that of control group significantly. MEBO has antibiotic function and may cooperate with bacteriophage.

4. Contact dermatitis and the strengthened ache not only increased the pain the sick suffered but also aggravated the damage to the wound and increased the infection chances of the wound and delayed the healing time of the wound. No toxicity and side effects occurred in MEBO group. However, there were 17 cases of contact dermatitis and 18 cases of strengthened ache occurred in control group. 

The curative effect of MEBO in treating skin and soft tissues abrasion was significant with slight toxicity and side effect.

Full Report:

Clinical Study on the Therapeutic Effect of MEBO in Treating Skin and Soft Tissue Abrasion, The Chinese Journal of Burns, Wounds and Surface Ulcers 2002(2): 106-108