Rhinopolypus extirpation and nasal concha expiration are ordinary nasal operations. 

Traditional hemostasia is using vaseline gauze strips to fill nasal cavity which can not relieve pain and improve wounds healing and discharge. 

Till now there are no good methods to prevent and cure complications after operation. 

Based on the characteristics of MEBO, we made MEBO gauze strip to fill nasal cavity as the treatment after operation. 

According to the comparison between the 108 patients treated with MEBO and 60 patients treated with Vaseline (control) after nasal cavity operation, MEBO gauze strip has hemostasis, acesodyne, anti-infection effects and can improve wound healing, abbreviate period of treatment, alleviate local edema and conglutination after operation, and reduce scars obviously. 

MEBO gauze strip was applied to tamp nasal cavity in treating. 

It is a new specific medicinal gauze strip to prevent and cure complications after operation. It can increase operation effects through its study and application.

Treatment methods

Making methods of MEBO gauze strip: gauze strips were disinfected under high pressure and MEBO was forged to make gauze strips for use with asceptic techniques (A great amount of MEBO was used, and the gauze strips made need no sterilization). 

In the treatment group after general rhinopolypus or nasal concha expiration, we applied MEBO gauze strip to tamp nasal cavity with the same means and tightness as in the traditional vaseline gauze strip tamping method. 

Take out MEBO gauze strips from nasal cavity every 24 hours, observe two times, apply MEBO upon wounds and keep for 3 days. In the control group, Vaseline gauze strips were adopted for tampoing, and they were taken out and observed every 36 hours[2].

Colloidal secretion should be cleared at any time, pennyroyal compounds was applied twice a day for 3 days. In order to observe the effects conveniently, the two groups of patients did not use antibiotics and hemostat. The patients with infection, fever, hemorrhage and unbearable pains should be treated with expectant medication.

MEBO, also called Moist Exposed Burn Ointment, is widely used in clinical practice. We made MEBO gauze strip, applied it in tamping treatment after nasal cavity operation and achieved better effects than Vaseline gauze strip. 

The main effects of it are:

1. MEBO can improve wound healing after nasal cavity operation. 

Wounds healing time in the MEBO group is 2-3 days shorter that in the Vaseline group. The reasons of improving healing are: 

• First, nasal cavity is the room for bacteria growth so wounds are prone to be infected. After applying MEBO on wounds, it can be liquefied to form a protective drug membrane to isolate the wounds from bacteria encroach and restrain bacteria growth thereby it has quite strong anti-infection effects and can provide advantageous environment for mucous membrane growth and recovery and wound healing, while Vaseline is bad for wound healing.[3] 
• Second, MEBO contains lots of nutrients, such as saccharide, protein and organic acid, etc., which can supply nutrition to the local areas directly and provide necessaries for the growth and healing of wounds to mucous membrane so as to improve wounds recovery. 
• Third, MEBO can improve local micro-circulation and strengthen local ability of blood transportation so as to promote local nutrient supply and then offer guarantee to mucous membrane growth and metabolism and avoid wound healing delay caused by local nutrition absence.
• Fourth, MEBO can discharge automatically and keep the wounds moist. Gauze strip made with MEBO is floppy, not stimulative, liquefied soon after filled in nasal cavity, and can eliminate metabolites and desquamative wounds tissues in time, remove micro-circulation obstacle, promote the growth of new tissues and retrieve vitality with slough tissues discharged without affecting paranasal sinus excretion and auditory tube function. Moist environment provides a good condition for cell growth in favor of wound healing.

2. MEBO has obvious analgesic effect. 

In nasal operation, narcosis tissues of exterior mucous membrane make patients feel pains during operation and the pains are worse after operation. 

Applying MEBO gauze strip tamping can relieve pains after operation and improve diet and sleep, strengthen immunity, remove the worries about the pains during taking out gauze trip. 

The mechanism of acesodyne is: 

• First, the protective membrane on the wounds replaces fibrin membrane (The protective membrane of MEBO is actually a mixed membrane of fibrin in secretion and MEBO altogether), and can avoid pains caused by bacteria and toxin. 
• Second, drugs in MEBO have quite effective anti-inflammation and anti-infection functions and can alleviate edema oppressive pains caused by local wounds.
• Third, MEBO can excrete exudation and metabolites via automatic circulation drainage so as to avoid them kept on the wounds which results in pains. 
• Fourth, MEBO gauze strip is floppy and has some cushion after filled in nasal cavity so as to avoid reflected headache caused by tamping. Based on analgesic mechanism, applying MEBO has perfect effects.

3. MEBO can alleviate scar formation. By improving local blood circulation, MEBO accelerates metabolism and prevents the deformation of mucous membrane epithelia in moist environment caused by growth setting change, relieves fibrin cell hyperplsia and alleviates scar formation. After the wounds heal, mucous membrane has good elasticity, slippery exterior, there is no apparent atrophy and hyperplasia, this is very important for the recovery of ventilation and smell sense [4] , and can reduce recurrence of disease. 

The effects of MEBO in keeping nasal cavity moist, avoids membrane desiccation and bleeding caused by respiration airflow and reduces conglutination rate of wounds and the surrounding tissues.

4. MEBO can prevent tissue edema around the wounds. 

In nasal operation, there is great stimulation to mucous membrane because of repeatedly putting appliances in and out which results in edema after operation. 

MEBO gauze strip is good for alleviating mucous membrane edema with the following reasons: 

• First, MEBO has effects of automatic circulation drainage to eliminate metabolites of tissues to avoid tissue edema.
• Second, MEBO has anti-infection function and can alleviate local inflamed edema. 
• Third, MEBO has protecting effect so as to avoid edema caused by bacteria toxin.

5. MEBO gauze strip has tamping hemostasis effects [5]. 

The protective membrane caused by MEBO gauze strip filled in nasal cavity and the pressure can stanch effectively. After taking out gauze strip the stimulation of respiration airflow will cause fibrin membrane desiccation and bleeding. 

Applying MEBO upon wounds and surrounding mucous membrane can keep moist os as to protect them and avoid bleeding after operation. 

Till now no hemostatic tamping matters have effects of analgesic, improving wounds healing and preventing complications after operation. 

We apply MEBO gauze tamping for multi-prupose. 

It has been proved by clinical observation that MEBO gauze strip is a new-generation tamping and ought to be popularized.

Reference:

1. Application of MEBO after Operation on Nasal Cavity (168 cases)