Is MEBO a kind of anti-biotic? If not, how can it prevent and control infection?Its effect of infection prevention and controlling is achieved by the property of MEBO combined with MEBT to achieve two approaches to non-bactericidal bio-control of bacteria as well as drainage and discharge of necrotic tissue on the basis of no secondary injury on viable residue and keeping favorable environment of healing and regeneration. The mechanism is as follows: 1. It controls infection by maintaining expedite drainage of wounds. This is achieved by
changing dressings every 4 to 6 hours, immediately removing and
cleaning up liquefied necrotic tissues in deep wounds to achieve
self–drainage effect of MEBO on wounds.
Moreover, the immediate application of ‘Ploughing Method’, ‘Necrotic Tissue Thinning method’ to remove necrotic tissues should be performed in time. Meanwhile viable tissues should not be damaged, thus decreases the absorption of necrotic tissues and toxins and reduces the occurrence of sepsis[27-29]. 2. The infection controlling on burns wound is accomplished by bio-control of bacteria and toxins. The laboratory research and
clinical practices revealed that in the micro-environment formed by
MEBO, non-genetic heteromorphosis could occur in bacteria,
the metabolism and propagation rate slows down, the quantities
decreased.
Furthermore, the bacteria toxicities decreased as well. It could also prevent the invasion of other bacteria effectively[30-34]. 3. A great deal of lipid ingredients contained in MEBO provide the nutrients and energy sources for skin regeneration, especially for the synthesis of cell membrane.
These ingredients do not only save topical agonal cells (See Q18,
Part1), but also provide nutrients and energies for proliferation of
skin stem cells and local activities of immunological cells after they
were absorbed into blood.
The palinesthesia of agonal cells and cells newly regenerated could reconstruct a tissue barrier to prevent from the invasion of microbes and swallow necrotic tissues and bacteria[27-29]. 4. The pharmacologically active ingredient in MEBO, could exert anti-inflammation effect similar to glucocorticoid after being absorbed into blood.
Therefore decrease the morbidity rate of SIRS (systemic inflammatory
response syndrome) and increase the non-specific immunity of the
organism (See Q19, Part1), thus to prevent the infection[27-29].
While, to be emphasized here, the anti-infection effect of MEBT/MEBO only signifies that it is unnecessary to apply antibiotics locally, but not mean to totally abandon the principle of applying antibiotics systemically. Systemic antibiotics application should be carried out according to different clinical conditions, and emphasize on the principle of early, high performance, low toxicity and short-term application (See Q1.6, Part 2). ※ The basic and clinical study on the anti-infection effect of MEBO is listed in reference [27-38] Reference: [27] ‘Study on the bacterial count of in vivo tissue of wound in burn’, Geng Xiulan, The Chinese Journal of Burns Wounds and Surface Ulcers 1989, 1 (1): 49-50 [28] ‘Experimental Studies on Promotion of Skin Wounds Healing and Anti-infection Effects’, Xing Dongming, The Chinese Journal of Burns Wounds and Surface Ulcers 1989, 1 (1): 51-52 [29] ‘Moist Exposed Therapy for Treating Pyocyanic Infection of Wounds’, Zhu Xiaoyuan, The Chinese Journal of Burns Wounds and Surface Ulcers 1992, 4 (2): 26-27 [30] ‘Experimental Research on the Anti-infective Mechanism of MEBO’, Qu Yun-ying, The Chinese Journal of Burns Wounds and Surface Ulcers 1996, 8 (1): 19-23 [31] ‘Experimental Research on the Mechanism of the Effect of MEBO’, Qu Yun-ying, The Chinese Journal of Burns Wounds and Surface Ulcers 1997, 9 (4): 4-9 [32] ‘Experimental Research on the Antibacterial Effect of MEBO’, Cui Xiu-zhen, The Chinese Journal of Burns Wounds and Surface Ulcers 1998, 10 (4): 15-17 [33] ‘Experimental Research on Anti-infection Effect of MEBO (Continued)’, Qu Yun-ying, The Chinese Journal of Burns Wounds and Surface Ulcers 2000, 12 (3): 44-47 [34] ‘A Comparative Analysis of 221 Strains of Bacteria on Infected Burn Wound Surface’, Yang Jinfu, The Chinese Journal of Burns Wounds and Surface Ulcers 1997, 9 (1): 14-18 [35] ‘A Comparative Study of the Effects of MEBO, Silver Sulfadiazine and Hot Dry Exposed Therapy on Controlling Pseudomonas Aeruginosa Infection of Burn Bounds’, Chen Xiao-wu, The Chinese Journal of Burns Wounds and Surface Ulcers 1990, 2 (3): 39-44 [36] ‘Observations on the Curative Effect of Treating 121 Cases of Purulent Sore with MEBO’, Li Wenxiang, Communication Medicine 2000, 14 (6): 649 [37] ‘An Analysis of 112 Cases of Infected Deep Burn Wounds Treated with MEBO’, Li Shouju, The Chinese Journal of Burns, Wounds and Surface Ulcers 2002, 14 (3): 167-169 [38] ‘Evaluating the Role of Alternative Therapy in Burn Wound Management: Randomized Trial Comparing Moist Exposed Burn Ointment With Conventional Methods in the Management of Patients With Second-degree Burns’, Erik Sze-Wee Ang, Medscape/General Medicine 2001, 12 (3): 3-18 |
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